Why we selected this company:

Supplements for Sensitive People
Pure Encapsulations supplements are hypoallergenic. There are absolutely no hidden fillers or coatings, binders, shellacs, artificial colors, fragrance or excipients in their products that would disrupt or diminish the bioavailability of any of our ingredients. Furthermore, their products are free of wheat, yeast, gluten, corn, sugar, starch, preservatives or hydrogenated oils.

Ingredient Quality
Their ingredients are selected solely on the basis of quality and purity and are provided in their most potent and bioavailable forms. They purchase premium raw materials from Japan, Switzerland, Germany, Italy, France, and of course, the U.S. Manufacturers of ingredients must pass rigorous pharmaceutical grade analytical tests to qualify as Pure Encapsulations suppliers.

Manufacturing and Quality Control Excellence
They manufacture their supplements in their own state-of-the-art facility in Sudbury, Massachusetts.  Their dedication to cleanliness is obvious from the moment their plant is entered. A large staff is dedicated full-time to the task of ensuring that their plant is impeccable.

Each step of the manufacturing process is governed by exacting standards and exceeds the requirements for nutritional supplement manufacturing. All manufacturing takes place in humidity- and dust-controlled individual rooms. Each piece of equipment used in the manufacture of Pure Encapsulations supplements is dismantled and sterilized before each production run. This includes scales, mills, blenders, powder fillers, encapsulating machines and capsule counters.

Each Pure Encapsulations lot is submitted to an independent laboratory for final confirmation of potency and conformance with ingredient levels. They are the only supplement manufacturer that has FDA certified laboratories test every batch of finished, encapsulated products.  This is an important distinction from companies that use in-house laboratories, use skip-lot testing or test ingredients prior to encapsulation or tableting.

All of their customers have access to the test results by viewing over 200 assays available on CD, verifying their uncompromising standards.

All finished products must also pass the USP Microbial Limits Test.  Our finished products are tested by Integrated Biomolecule Corporation, Vanguard Scientific, Eurofins Scientific and Advanced Food Micro.

Why we selected this product:

HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults.
Zenk JL, Frestedt JL, Kuskowski MA.

Department of Clinical Affairs, Minnesota Applied Research Center, Edina, MN 55435, USA. john@zenk.net

This study tested the hypothesis that 3-acetyl-7-oxo-dehydroepiandrosterone alone (7-Keto) and in combination with calcium citrate, green tea extract, ascorbic acid, chromium nicotinate and cholecalciferol (HUM5007) will increase the resting metabolic rate (RMR) of overweight subjects maintained on a calorie-restricted diet. In this randomized, double-blind, placebo-controlled, crossover trial, overweight adults on a calorie-restricted diet were randomized to three 7-day treatment periods with 7-Keto, HUM5007 or placebo. Resting metabolic rate was measured by indirect calorimetry at the beginning and end of each treatment period with a 7-day washout between testing periods. Of 45 subjects enrolled, 40 completed the study (30 women, 10 men; mean age, 38.5 years; mean mass index, 32.0 kg/m(2)). During the placebo treatment, RMR decreased by 3.9% (75+/-111 kcal/day; mean+/-S.D.); however, RMR increased significantly by 1.4% (21+/-115 kcal/day) and 3.4% (59+/-118 kcal/day) during the 7-Keto and HUM5007 treatment periods, respectively (each compared to placebo, P=.001). No significant differences were found between the treatment periods with respect to compliance or adverse events. In this study, the administration of HUM5007 or 7-Keto reversed the decrease in RMR normally associated with dieting. HUM5007 and 7-Keto increased RMR above basal levels and may benefit obese individuals with impaired energy expenditure. HUM5007 and 7-Keto were generally well tolerated and no serious adverse events were reported.

PMID: 17418559 [PubMed - indexed for MEDLINE]
J Nutr Biochem. 2007 Sep;18(9):629-34. Epub 2007 Apr 5.

Benefits for the body:
Metabolic support, weight management, and immune-boosting properties

Interesting factors:
7-KETO DHEA, a safe and natural metabolite of DHEA, was the subject of research for over a decade at the University of Wisconsin in Madison. Of over 150 DHEA compounds tested, 7-KETO proved to be the most promising form. Researchers discovered that 7- KETO does not convert to testosterone or estrogen, minimizing androgenic activity, and supports various physiological processes. It is several times more potent than DHEA in stimulating the thermogenic enzymes of the liver, promotes basal metabolism, and helps to increase the lean/adipose ratio. These actions safely support a leaner BMI (Body Mass Index) and healthy weight control. 7-KETO DHEA is also known as DHEA-Acetate-7-one, 3-acetoxy-androst-5-ene-7, 17-dione, or 3-acetyl-7-oxo- dehydroepiandrosterone.

The term 7-Keto is in fact a brand name for the chemical compound 3-acetyl-7-oxo-dehydroepiandros-terone, a naturally occurring metabolite primarily produced in the adrenal glands and skin (though some production occurs in the brain as well). It was first discovered in 1958, when it was found in urine. Human blood levels of 7-Keto tend to follow the same course over time as those of DHEA, rising until about the age of 20 and then slowly descending beginning around the age of 30. Urinary excretion studies show that average blood concentrations of 7-Keto decline nearly 50% by age 50.

Ingredients:
DHEA-Acetate-7-one ...25mg

Contains - Hypo-Allergenic Plant Fiber, Vegetable Capsule

Does Not Contain - Hidden Coatings, Exciopients, Binders, Fragrance, Dairy, Wheat, Yeast, Gluten, Corn, Sugar, Starch, Soy, Preservatives, Hydrogenated Oils

Dosage:
As a dietary supplement, take 1-8 capsules daily, in divided doses, with meals.

WARNINGS:
Store sealed in a cool dry place. Keep out of reach of children. Use only if safety seal is intact.

Not to be taken by pregnant or lactating women.

*These statements have not been evaluated by the FDA.  If in doubt consult with a licensed naturopathic physician before use.  Physicians at Genesis Health Systems can be reached at 480.284.8155 and we are happy to consult with you about this product and helping you achieve optimal health.