Why we selected this company:

Premier Research Labs is known internationally as the pre-eminent manufacturer of excipient-free, premier quality nutraceutical formulations, super food concentrates and the world's first producer of quantum cellular resonance products that are capable of restoring quantum coherence to the body's inherent biofield.  Fully functional coherence of the biofield is the new and most comprehensive definition of anti-aging therapy, born out of quantum physics.

Why we selected this product:

Beta-lapachone, a quinone isolated from Tabebuia avellanedae, induces apoptosis in HepG2 hepatoma cell line through induction of Bax and activation of caspase.

Woo HJ, Park KY, Rhu CH, Lee WH, Choi BT, Kim GY, Park YM, Choi YH.

Department of Biochemistry, Dongeui University College of Oriental Medicine, Busan, Korea.

The DNA topoisomerase inhibitor beta-lapachone is a quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) in South America. It has been reported to possess a wide range of pharmacological properties, and is a promising cancer chemopreventive agent. In this study, the effects of beta-lapachone on the growth of the human hepatoma cell line HepG2 were investigated. The results showed that beta-lapachone inhibits the viability of HepG2 by inducing apoptosis, as evidenced by the formation of apoptotic bodies and DNA fragmentation. Reverse transcription-polymerase chain reaction and immunoblotting results indicated that treatments of cells with beta-lapachone resulted in down-regulation of anti-apoptotic Bcl-2 and Bcl-X(L) and up-regulation of pro-apoptotic Bax expression. beta-Lapachone-induced apoptosis was associated with a proteolytic activation of caspase-3 and -9 and degradation of poly(ADP-ribose) polymerase protein. However, beta-lapachone treatment did not affect the inhibitor of apoptosis proteins family and the Fas/FasL system. Taken together, our study indicated that beta-lapachone may have potential as a chemopreventive agent for liver cancer.

PMID: 16822200 [PubMed - indexed for MEDLINE
J Med Food. 2006 Summer;9(2):161-8.

Benefits for the body:
Support for liver, gallbladder and immune system.

Interesting facts:
The inner bark of the true Pau D’Arco has been used historically as a folk remedy for a wide variety of conditions such as:  boils, colitis, diarrhea, dysentery, bedwetting, fever sore throat, snakebite, syphilis, wounds, ulcers, respiratory problems, arthritis, cystitis, constipation, prostatitis, poor circulation, and many forms of cancer (esophagus, head, intestine, lung prostate, and tongue).

Worldwide research has shown anti-microbial, anti-viral, anti-bacterial and anti-parasitic activity for true Pau D’Arco.  In addition, the naphthoquinones of Pau D’Arco have been found to be highly effective against Candida albicans, the common yeast organism causing candidiasis infections.

Ingredients:
425 mg/ Vegetable caps
Genuine Pau D’Arco (bark) (Tabebuia impetiginosa), certified by the Brazilian government.

*These statements have not been evaluated by the FDA.  If in doubt consult with a licensed naturopathic physician before use.  Physicians at Genesis Health Systems can be reached at 480.284.8155 and we are happy to consult with you about this product and helping you achieve optimal health.